Furthermore clinical pharmacologists consider anti epi leptic drugs as model drugs in pharmacokinetics and pharmocodynamics since reliable methods are available for their determination and their effects and side effects can be defined the methods of estimating of drugs in body fluids provide a tool that enables us to throw light on many obscure relationships in pharmaceutical treatment . Clinical pharmacology of anti epileptic drugs workshop on the determination of anti epileptic drugs in body fluid ii wodadibof ii held in bethel bielefeld germany 24 25 may 1974 englisch taschenbuch 1 januar 1975 von h schneider herausgeber d janz series editor. Pht michaelis menton kinetic parameters have been reported to clinical pharmacology of antiepileptic drugs 181 be unchanged in aged patients compared with controls in the literature but a study in patients over the age range 21 to 78 found a 15 decrease in maximal rate of pht biotransformation vmax560 thus patients would tend to develop higher pht levels for the same doses than younger patients as steady state concentration varies inversely with vmax. Despite the availability of newer agents a number of antiepileptic drugs have continued to be employed reasonably widely many years after their introduction to human therapeutics these drugs comprise phenobarbitone and some of its congeners phenytoin ethosuximide carbamazepine valproate and certain benzodiazepines
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